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Updated: Jun 17, 2026

Identification of Kinase-substrate Pairs Using High Throughput Screening
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Identification of Kinase-substrate Pairs Using High Throughput Screening

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在Kinase药物发现中的基准测试交叉对接策略

David A Schaller1,2, Clara D Christ3, John D Chodera2

  • 1In Silico Toxicology and Structural Bioinformatics, Institute of Physiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

Journal of chemical information and modeling
|November 19, 2024
PubMed
概括

精确预测蛋白质-配体复杂结构对于药物发现中的机器学习至关重要. 结合对接方法和使用多种蛋白质结构,改善了对激酶抑制剂的姿势预测精度.

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Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include: