功能性神经障碍患者间接接收的改变神经处理:基于任务的fMRI研究
Petr Sojka1, Tereza Serranová1, Sahib S Khalsa1
1Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague (Sojka, Serranová); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, and Laureate Institute for Brain Research, Tulsa, Oklahoma (Khalsa); Functional Neurological Disorder Unit, Division of Behavioral Neurology and Integrated Brain Medicine, Department of Neurology, Division of Neuropsychiatry, Department of Psychiatry, and Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston (Perez); Functional Neurological Disorder Unit, Division of Behavioral Neurology and Integrated Brain Medicine, Department of Neurology, Athinoula A. Martinos Center for Biomedical Imaging, and Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston (Diez).
功能神经障碍 (FND) 患者表现出被破坏的整感受,影响大脑区域,如胰岛和带带皮质. 这些发现突出了FND评估和监测的潜在生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 受到干扰的整感受与功能神经障碍 (FND) 有关.
- 之前没有任何功能神经成像研究研究了FND患者的整感应信号处理.
研究的目的:
- 在使用功能性MRI的FND患者体内接收期间检查神经反应.
- 探索神经活动,心跳计数精度和FND中的感知性特征预测错误 (ITPE) 之间的关系.
主要方法:
- 功能性MRI (fMRI) 用于比较38名FND患者和38名健康对照者的神经反应.
- 参与者执行了一项涉及注意心脏整接收与外接收或休息的任务.
- 单变量和多变量分析研究了大脑活动,将其与行为指标相关联.
主要成果:
- 与HC相比,FND患者在右前胰岛和双侧背前带状皮层的神经活化减少.
- 在FND患者中,心跳计数的准确性与右前侧胰岛和中腹前额叶皮层激活具有积极的相关性.
- 互感准确度和ITPE得分显示了与关键大脑区域的神经活动的复杂相关性.
结论:
- 这项研究揭示了FND的状态和特征互感性干扰.
- 研究结果表明,带岛 ( Salience 网络) 区域与功能性和运动障碍的病理生理学有关.
- 这些结果表明,神经生理学评估和生物标志物可能用于FND的预后和监测.
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