认知障碍的纵向模式和预测因素分类稳定性
Cynthia McDowell1,2, Nicholas Tamburri1,2, Jodie R Gawryluk1,2,3
1Department of Psychology, University of Victoria, Cornett Building A236, 3800 Finnerty Road (Ring Rd), Victoria, BC, V8P 5C2, Canada.
概括
认知障碍,没有痴呆症 (CIND) 状态通常不稳定,许多人随着时间的推移而逆转或波动. 病前智商和损伤严重程度预测了这些认知变化.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 认知心理学 认知心理学
背景情况:
- 认知障碍,没有痴呆症 (CIND) 被认为是痴呆症的临床前阶段.
- 新出现的证据表明,CIND是一种不稳定的分类,并不总是进展为痴呆症.
研究的目的:
- 为了探索CIND状态的纵向稳定性模式.
- 为了确定6年CIND稳定的基线预测因素.
主要方法:
- 纵向重复测量的设计 (N=259,65-90岁).
- 潜伏过渡分析,以追踪每年CIND状态的变化.
- 多项逻辑回归用于评估基线预测因素.
主要成果:
- 观察到高回归率和CIND状态的波动.
- 病发前的智商和CIND严重程度在基线显著预测稳定性结果.
结论:
- 在基线后的几年里,CIND状态显示不稳定.
- 认知储备可以防止认知障碍.
- 最初的CIND严重程度会影响分类的准确性.
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