在头部和部恶性瘤中,化学辐射疗法诱导的听力损伤
Jitendra Kumar Jangir1, Sunita Agarwal1, Pawan Singhal1
1Department of Otorhinolaryngology, SMS Medical College, Jaipur, Rajasthan India.
概括
对头癌的放射/化疗会导致听力损失. 早期检测和监测对于管理感觉神经听力损失 (SNHL) 和改善患者生活质量至关重要.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 在瘤学瘤学.
- 听力学 听力学是指听力学.
背景情况:
- 头部和部癌症治疗,如放射/化疗,可能导致听力损失.
- 这种听力损失可以显著影响患者的沟通和社会福祉.
- 早期发现听力损失对于及时干预和改善生活质量至关重要.
研究的目的:
- 为了前性地评估头部和部恶性瘤的放射/化疗患者的听力损失的发生率和程度.
- 分析治疗方式,思普拉丁剂量和感觉神经听力损失 (SNHL) 的发展之间的关系.
主要方法:
- 一年期前性观察性研究,涉及90名头部和部恶性瘤患者.
- 治疗前和治疗后1个月和6个月的时间间隔进行纯音声声度测试.
- 收集和分析了治疗方式 (放射治疗,化疗,化疗放射治疗) 和西斯普拉丁剂量的数据.
主要成果:
- 化学放射治疗 (81.1%),放射治疗 (48.5%) 和化疗 (50%) 都导致了神经感官听力损失 (SNHL).
- 高剂量西斯与较低剂量西斯相比,与更严重的SNHL等级 (2和3) 有显著的关联.
- 根据治疗方式和药物剂量,SNHL的发病率和严重程度各不相同.
结论:
- 化疗和放射治疗,特别是高剂量西斯,是头癌患者SNHL的重要原因.
- 建议定期进行听力测量监测,以检测和管理治疗引起的听力损失.
- 治疗方案可能需要根据听力损失监测进行调整,可能涉及剂量修改或药物替代.
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