唾液pH测试在喉喉反流性疾病中
Chethana R1, Amruta Chutke2, Rohit Jadhav1
1Department of ENT Bharati Vidyapeet (Deemed to be), University Medical college, Pune, 411046 Maharashtra India.
概括
在患有喉回流症 (LPR) 患者和健康个体之间,唾液pH值显著不同. 与预期相反,一些LPR患者的唾液pH值高于正常,这表明唾液pH值可能不是可靠的LPR诊断工具.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 胃肠病学 胃肠病学
- 生物化学 生物化学
背景情况:
- 喉回流 (Laryngopharyngeal Reflux,简称LPR) 是一种胃内含物回流到喉的情况.
- 了解LPR的生理标记对于诊断和管理至关重要.
- 唾液pH值是一个潜在的,但尚未证实的,LPR的指标.
研究的目的:
- 为了研究与健康个体相比,LPR患者的唾液pH值差异.
- 探索唾液pH值作为LPR的诊断标记物的潜力.
主要方法:
- 一项涉及64名成年参与者的横截面分析研究 (32名LPR,32名非LPR).
- 基于反流症状指数 (RSI) 和反流发现得分 (RFS) 的LPR诊断.
- 所有参与者的唾液pH值使用标准化pH值计进行测量.
主要成果:
- 在LPR组 (7.43 ± 0.77) 和非LPR组 (7.0 ± 0.77) (p=0.004) 之间观察到平均唾液pH值的统计学上显著差异.
- 一个值得注意的发现是,31.2%的LPR患者的唾液pH值>7.6,这与酸性pH的假设相矛盾.
- 大多数LPR患者 (68.8%) 的唾液pH值在正常范围内.
结论:
- 这项探索性研究揭示了LPR和非LPR组之间的唾液pH在统计学上显著的差异.
- 单独的唾液pH值并不是LPR的确的诊断方式,原因是意外的发现和小样本大小.
- 建议使用精细的方法进行进一步的研究,以澄清唾液pH在LPR中的作用.
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