塞尔B9在肺腺癌中表达很高,与无进展生存相关
Yue Fang1,2, Yi Yue3, Sensen Hao1
1Galactophore Oncology Center, Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei City, Anhui Province, People's Republic of China.
Journal of inflammation research
|November 19, 2024
概括
肺腺癌组织中的高塞尔B9表达与预后不佳和免疫疗法的有效性降低相关. 这一发现突出了Serpin B9作为改善患者结果的潜在目标.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 塞尔B9抑制自然杀手 (NK) 细胞介导的细胞毒性.
- 之前关于Serpin B9在癌症中的作用的研究仅限于体外和体内模型.
- 对患者瘤组织中Serpin B9表达的系统研究及其预后意义缺乏.
研究的目的:
- 评估肺腺癌 (LUAD) 患者瘤组织中的Serpin B9表达水平.
- 为了确定Serpin B9表达和患者预后之间的相关性.
- 评估Serpin B9表达与LUAD免疫疗法的疗效之间的关系.
主要方法:
- 免疫组织化学 (IHC) 用于评估200名LUAD患者的瘤和相邻组织中的Serpin B9表达.
- 根据H-score,患者被分为高和低的Serpin B9表达群.
- 统计分析包括t测试,奇平方测试,考克斯回归和卡普兰-梅尔生存分析.
主要成果:
- 与邻近组织相比,LUAD瘤组织中的Serpin B9表达显著更高.
- 增加的塞尔B9水平与TNM阶段有正相关,与无进展生存期 (PFS) 有负相关.
- 免疫疗法疗效与塞尔B9表达呈反相关性.
结论:
- 在LUAD中增加的Serpin B9表达与更差的预后有关.
- 塞尔B9的表达水平与免疫治疗的有效性相反.
- 塞尔B9具有潜在的预后生物标志物和肺腺癌的治疗标.
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