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Updated: Jun 18, 2026

Direct Induction of Hemogenic Endothelium and Blood by Overexpression of Transcription Factors in Human Pluripotent Stem Cells
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从人类诱导的多能干干细胞中有效地产生肝侧侧内皮样细胞,分泌凝血因子VIII

Seiji Mitani1, Chihiro Hosoda1, Yu Onodera1

  • 1Advanced Medical Science of Thrombosis and Hemostasis, Nara Medical University, Kashihara, Nara 634-8521, Japan.

Molecular therapy. Methods & clinical development
|November 19, 2024
PubMed
概括

研究人员优化了干细胞的分化,以产生肝脏内皮状内皮细胞 (LSEC) 和祖先细胞 (LPC). 这些细胞在体外有效地产生凝血因子VIII (FVIII),为血友病A细胞治疗提供了潜力.

关键词:
凝血因子VIII是什么不同化的差异化差异化.血友病A型 血友病A型 血友病A型人类诱导的多能干细胞干细胞.肝脏的阴侧内皮细胞内皮细胞.

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