视觉脂肪作为2型糖尿病中糖尿病外围神经病变的独立风险因素:一项回顾性研究
Rui-Ling Wu1, Niyao Chen2, Yanni Chen3
1Department of Clinical Nutrition, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Journal of diabetes research
|November 19, 2024
概括
内脏脂肪区域是2型糖尿病 (T2DM) 患者糖尿病外围神经病变 (DPN) 的独立风险因素. 评估内脏肥胖症在早期DPN预防和管理中的帮助.
科学领域:
- 内分泌学 在内分泌学.
- 代谢过程中的代谢.
- 神经学 神经学
背景情况:
- 糖尿病外围神经病变 (DPN) 影响了约50%的2型糖尿病 (T2DM) 患者,增加了脚和截肢的风险.
- 内脏脂肪是DPN发展的关键因素.
- 早期识别患有DPN高风险的T2DM患者至关重要.
研究的目的:
- 评估T2DM患者与肥胖相关的身体成分,特别是内脏脂肪和DPN之间的相关性.
- 确定内脏脂肪作为DPN的潜在独立风险因素.
- 为了促进T2DM中DPN的早期风险分层.
主要方法:
- 对113名T2DM患者进行横截面研究.
- 分类为DPN和非DPN (NDPN) 组.
- 生物电阻分析 (BIA) 用于身体组成 (包括内脏脂肪区域) 和临床/生化数据收集.
- 物流回归分析. 物流回归分析.
主要成果:
- 在DPN和NDPN组之间观察到内脏脂肪面积的显著差异 (p=0.048).
- 多变量逻辑回归确定了内脏脂肪区域作为DPN的独立风险因素 (OR 1.027,p=0.022).
- 糖尿病持续时间和糖尿病视网膜病变也是显著的危险因素.
结论:
- 内脏脂肪区域是T2DM患者DPN的独立风险因素.
- 管理内脏肥胖对于DPN预防和管理至关重要.
- 在临床和社区环境中,BIA对早期DPN检测有价值.
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