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Updated: Jun 7, 2025

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
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Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

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为结肠癌治疗而开发的新型N--2-氨酸) 胺化盐

Yan Peng1, Ying Peng1, Wei Zhang1

  • 1School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

Frontiers in pharmacology
|November 19, 2024
PubMed
概括

新型化水盐形式N53·HCl通过提高其溶解性和药理动力学特性,显著提高了N53的抗结肠癌疗效. 这种改进的候选药物在体内表现出优异的抗瘤活性和结肠癌治疗的安全性.

关键词:
这是Topo I和COX-2双抑制剂.它具有抗结肠癌活性.含有化的化水.药物动力学属性 药物动力学属性在水中溶解度水溶性.

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