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基线炎症状况会影响他类药物在患有外周动脉疾病的患者的预后影响

Kentaro Jujo¹, Daisuke Ueshima², Takuro Abe¹

¹Department of Cardiology, Nishiarai Heart Center Hospital, Tokyo, Japan.

American heart journal plus : cardiology research and practice

|November 19, 2024

概括

类药物改善了周围动脉疾病 (PAD) 患者的结果,特别是那些炎症严重的患者. 这项研究发现,他类药物的益处在患有高C反应蛋白 (CRP) 水平的患者中最为显著.

科学领域:

心脏病学心脏病学
血管医学血管医学
药理学药理学是指药理学的学科.

背景情况:

已知他类药物具有抗炎性,有利于动脉样硬化疾病.
它们对外围动脉疾病 (PAD) 的预后效果需要进一步验证.
炎症水平可能会影响PAD患者的他类药物的疗效.

研究的目的:

为了研究他类药物在PAD患者的预后影响.
为了确定他类药物的效果是否因炎症水平而有所不同,由C-反应蛋白 (CRP) 评估.

主要方法:

一项前性队列研究的细分分析,涉及1974年接受内血管治疗 (EVT) 的PAD患者.
根据基线CRP水平,患者被分为四组.
在每个CRP类别内的他类药物使用者和非使用者之间的复合终点 (死亡,中风,心肌梗塞,大截肢) 的比较.

主要成果:

总的来说,他类药物使用者与非使用者相比,事件发生率明显较低 (11.0%与18.7%,p < 0.001).
在中高和高CRP类别 (分别p=0.02和p=0.008) 中,静止剂治疗显著降低了事件率.
多变量分析证实,仅在高CRP组 (aHR:0.64 [0.41-0.98]) 中,他类药物的使用独立地与初级终点的较低风险相关.

结论:

类固醇治疗可能在PAD患者中提供有利的预后效果.
这些益处在显著升高炎症的患者中显得最明显,由高CRP水平表明.

关键词:

在C-反应性蛋白质中.血管内治疗治疗血管内治疗周围动脉疾病是什么?类他类药物是一种药物.

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