与中风死亡率和心血管结果相关的NSAID过敏标签
Cheryl C W Tsui1, Hugo W F Mak1, William C Y Leung2
1Division of Rheumatology and Clinical Immunology (C.C.W.T., H.W.F.M., P.H.L.), Department of Medicine, The University of Hong Kong, Pokfulam.
错误标记的非类固醇抗炎药物 (NSAID) 过敏在中风患者中很常见,导致更糟糕的结果和更高的死亡率. 准确的过敏评估和干预可以改善患者的护理和降低风险.
科学领域:
- 神经学 神经学
- 临床药理学 临床药理学
- 流行病学 流行病学
背景情况:
- 错误标记的药物过敏会对患者护理产生负面影响,但其在中风患者中的患病率和影响尚不清楚.
- 这项研究解决了关于中风患者常见药物过敏标签的准确性和后果的知识差距.
研究的目的:
- 确定缺血性中风患者常见药物过敏标签的流行率和准确性.
- 调查这些过敏标签对药物处方,死亡率和中风后心血管不良事件的影响.
主要方法:
- 一项结合的纵向和横截面研究,使用来自香港 (2008-2014) 的电子健康记录.
- 一般人群和中风患者之间的过敏标签患病率的比较.
- 分析结果,包括阿司匹林处方率,死亡率和主要心血管不良事件,在中风患者和没有非类固醇抗炎药物 (NSAID) 过敏标签.
- 挑测试用于确认NSAID过敏标签的准确性.
主要成果:
- 与普通人群相比,中风患者患心血管/造血和放射/诊断剂过敏的患病率更高.
- 非类固醇抗炎药物 (NSAID) 过敏标签是最常见的 (1.8%) 并显著降低了阿司匹林处方率.
- 患有NSAID过敏标签的患者面临死亡率增加,周围血管疾病和主要心血管不良事件.
- 挑测试显示,80%的患有NSAID过敏标签的患者被错误标记.
结论:
- 非类固醇抗炎药物 (NSAID) 过敏标签在中风患者中普遍存在,并与较差的健康结果和增加的死亡率有关.
- 错误标记的NSAID过敏的高率强调了需要多学科的神经过敏干预措施,以改善患者的管理和结果.
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