怀孕中痛风:产科和新生儿结局
Sam Amar1, Ahmad Badeghiesh2, Haitham Baghlaf3
1Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada.
概括
由痛风复杂化的怀孕增加了妊娠糖尿病,手术分娩和静脉血栓栓塞的风险. 怀孕期间的痛风也会增加新生儿患有先天性异常的可能性.
科学领域:
- 产科和妇科 产科和妇科
- 类风湿病学 类风湿病学
- 新生儿健康 新生儿健康
背景情况:
- 痛风是一种代谢性疾病,其特征是高尿血和尿酸结晶沉积.
- 对于患有痛风的人来说,关于怀孕结果的数据有限.
- 基于人口的研究对于了解痛风对母亲和新生儿健康的影响至关重要.
研究的目的:
- 调查痛风与怀孕,分娩和新生儿后果之间的关联.
- 为了评估有痛风病史的孕妇产科并发症.
- 用国家数据评估患有痛风的孕妇的新生儿健康状况.
主要方法:
- 基于人口的回顾性队列研究.
- 利用了医疗保健成本和利用项目,全国住院患者样本 (HCUP-NIS) 从2004年至2014年.
- 患有痛风和没有痛风的孕妇之间的比较结果 (ICD-9诊断).
主要成果:
- 患有痛风的孕妇年龄较大,更容易肥胖,并患有高血压和糖尿病等并发症.
- 痛风与更高的妊娠糖尿病 (aOR1.78),手术性阴道分娩 (aOR3.26) 和静脉血栓栓塞 (aOR8.47) 相关.
- 患有痛风的母亲产生的新生儿患有先天性异常的风险增加 (aOR 3.38).
结论:
- 怀孕期间的痛风与母亲的不良后果有关,包括妊娠期糖尿病和肺栓塞.
- 患有痛风并发症的怀孕对新生儿先天性异常的风险更高.
- 对于怀孕期间的痛风管理,需要进一步的研究和临床关注.
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