治疗性BCG疫苗可以预防长期COVID:BATTLE随机临床试验
Mehrsa Jalalizadeh1, Keini Buosi1, Cristiane F Giacomelli1
1UroScience, State University of Campinas, Unicamp, Campinas, São Paulo, Brazil.
Journal of internal medicine
|November 19, 2024
概括
在一项为期12个月的试验中,在COVID-19康复期间使用的Bacillus Calmette-Guérin (BCG) 疫苗显著减少了长期COVID症状,如听力,睡眠和视力问题. 观察到性别特异性的影响.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 临床试验 临床试验
背景情况:
- 在COVID-19康复期间的Bacillus Calmette-Guérin (BCG) 疫苗接种显示出早期的承诺,用于解和失湿症的恢复.
- 战斗试验调查了BCG的长期结果在轻度COVID-19的成年人.
研究的目的:
- 评估Bacillus Calmette-Guérin (BCG) 疫苗在预防和减轻长期COVID症状方面的长期疗效.
- 在COVID-19后的条件下分析BCG免疫调节效应的机制方面.
主要方法:
- 进行了一项双盲,安慰剂控制,随机临床试验 (1:1比率).
- 参与者接受了皮内BCG疫苗或安慰剂.
- 在6个月和12个月后进行了后续评估,包括症状评估和机制分析.
主要成果:
- 在6个月后,BCG的使用显著减少了听力问题 (OR=0.26).
- 在12个月后,BCG减少了睡眠,注意力,记忆和视力问题 (ORs从0.36到0.45不等).
- 敏感性分析证实6个月和12个月的长期COVID症状总体减少 (p<0.05). 在6个月后,人们注意到对脱发的矛盾性性别特异性影响.
结论:
- 战斗试验的长期随访表明,BCG在康复期间给予时,可以提供对长期COVID发展的保护.
- BCG的免疫调节作用,可能涉及Fas联接体抑制和细胞因子诱导 (IL6,IL10,等等). ),可能是其保护机制的基础.
- 个人对BCG的反应各不相同,某些副作用的性别差异显著.
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