结直肠癌患者的完整血清参数和与炎症相关的生物标志物
Martha Koržinek1, Ivana Ćelap1,2, Marija Fabijanec1
1University of Zagreb Faculty of Pharmacy and Biochemistry Department of Medical Biochemistry and Hematology 10000 Zagreb, Croatia.
在结直肠癌 (CRC) 和腺瘤患者之间,全血细胞计 (CBC) 和炎症生物标志物有所不同. 虽然一些标记物显示出显著的差异,但它们对CRC的诊断准确性很差.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 生物标志物 生物标志物
背景情况:
- 结肠直肠癌 (CRC) 和腺瘤是不同的结肠直肠疾病.
- 完整血清 (CBC) 参数和炎症生物标志物可能反映疾病状态.
研究的目的:
- 调查CRC和结直肠腺瘤患者之间CBC参数和炎症生物标志物的差异.
- 评估这些生物标志物的诊断实用性,以区分CRC与腺瘤.
主要方法:
- 155名患者 (74名腺瘤,81名CRC) 接受了CBC分析和C反应蛋白 (CRP) 测量.
- 统计分析包括接收器运行特征 (ROC) 曲线分析.
主要成果:
- 与腺瘤患者相比,CRC患者表现出较低的血红蛋白,血红素,MCV,MCH,MCHC,总白细胞,中性粒细胞,单细胞以及较高的RDW,乙素和基素.
- 在CRC患者中,血小板数量较高,MPV较低.
- MPV/PC和PLR显著不同,但ROC分析显示所有测试参数的诊断准确性较差 (AUC ≤ 0.7).
结论:
- 在CRC和腺瘤患者之间,CBC参数和某些炎症生物标志物存在显著差异.
- 在CRC中降低血红蛋白可能与出血有关,而升高的基和乙酸表明炎症.
- 尽管存在统计上的差异,但这些生物标志物在区分CRC和腺瘤的诊断价值有限.
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