干预性瘤学与免疫瘤学相遇:肝细胞癌的组合疗法
Ryan Bitar1, Riad Salem1, Richard Finn1
1From the Departments of Radiology (R.B., J.C.) and Digestive Diseases (Hepatology) (J.C.), Yale University School of Medicine, New Haven, Conn; Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill (R.S.); Department of Medical Oncology, Geffen School of Medicine, University of California Los Angeles, Los Angeles, Calif (R.F.); Center for Cancer Research, National Institutes of Health, Bethesda, Md (T.F.G.); Department of Radiology, Hadassah Hebrew University Medical Center, Hebrew University, Jerusalem, Israel (S.N.G.); and Department of Biomedical Engineering, Yale School of Engineering and Applied Sciences, 789 Howard Ave, Clinic Bldg 363H, New Haven, CT 06520 (J.C.).
新型免疫疗法与图像导向疗法相结合,正在改变肝细胞癌 (HCC) 管理. 本综述探讨了将局域疗法与HCC的免疫疗法结合起来,包括临床试验和生物标志物.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 免疫治疗是一种免疫疗法.
背景情况:
- 肝细胞癌 (HCC) 管理正在随着新的免疫疗法而发展.
- 将免疫疗法与图像引导的局部区域疗法相结合是一种有前途的方法.
研究的目的:
- 审查免疫治疗在HCC管理中的作用.
- 讨论将局部治疗与免疫疗法结合在一起的理由和正在进行的试验.
- 突出 HCC 管理的成像终点和生物标志物.
主要方法:
- 关于HCC治疗的当前文献的综述.
- 对瘤微环境机制的分析.
- 目前正在进行的临床试验结合免疫疗法和局部区域治疗的总结.
主要成果:
- 免疫疗法正在成为HCC的标准护理.
- 超过50个临床试验正在研究免疫疗法与局部区域疗法相结合.
- 开发成像终点和生物标志物至关重要.
结论:
- 免疫疗法和局部区域治疗的联合治疗显示出对HCC的显著潜力.
- 干预放射科医生在使用这些新的方法来管理HCC方面发挥着关键作用.
- 对生物标志物和成像的进一步研究对于优化治疗至关重要.
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