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在ITPR3中占主导地位的负变异会损害T细胞Ca2+动态,导致联合免疫缺陷

Elena Blanco1, Carme Camps2,3, Sameer Bahal1

  • 1Molecular and Cellular Immunology, Great Ormond Street Institute of Child Health, University College London , London, UK.

The Journal of experimental medicine
|November 19, 2024
PubMed
概括

ITPR3中的遗传变异通过破坏T细胞中的 (Ca2+) 信号传递,导致联合免疫缺陷 (CID). 这会损害T细胞的发育和功能,导致免疫系统缺陷和多系统性疾病.

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