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"开发,优化和表征基于Eudragit的纳米颗粒用于达沙替尼的输送"

Hemanth G¹, Anasuya Patil¹, Hariprasad Mg²

¹Department of Pharmaceutics, KLE College of Pharmacy, Bengaluru, India.

Journal of biomaterials science. Polymer edition

|November 19, 2024

概括

装有达沙替尼的纳米颗粒 (DST-NP) 在乳腺癌治疗方面表现有前途. 这些纳米粒子提高了药物的生物可用性,有效地向瘤,并在临床前模型中显示出显著的抗癌疗效.

科学领域:

纳米技术纳米技术
材料科学材料科学材料科学
在瘤学瘤学.

背景情况:

乳腺癌仍然是全球主要的死亡原因,需要新的治疗策略.
传统化疗面临诸多挑战,包括生物可用性差和非向性毒性.
基于纳米粒子的药物输送系统为提高癌症治疗效率提供了潜在的解决方案.

研究的目的:

开发和描述使用Eudragit L100用于改善乳腺癌治疗的达沙替尼装载纳米粒子 (DST-NP).
评估DST-NP的体外和体内性能.
评估DST-NP的药理动力学,生物分布,疗效和安全性概况.

主要方法:

使用Eudragit L100.制备达沙替尼带纳米粒子 (DST-NP) 的方法.
对于粒子大小,泽塔潜力和捕获效率来说,DST-NP的表征.
在体外释放药物,细胞毒性测定 (MTT) 和稳定性研究.
在生体内对大鼠的药理动力学,组织分布,疗效 (DMBA诱导的乳腺癌模型),血液学和组织病理学分析.

主要成果:

优化的DST-NP显示出有利的物理化学特性 (202.1纳米大小,-18mV泽塔电位,93.11%的捕获效率).
观察到持续的体外药物释放,增强的体内生物可用性 (更高的Cmax和AUC0-t),以及改善瘤向.
DST-NP显著降低了瘤体积,改善了生存率,表现出有利的血液学概况,并恢复了正常的组织结构.
与纯达沙替尼相比,对乳腺癌细胞系 (MCF-7,MDA-MB231,4T1) 的细胞毒性较高,IC50值较低.

结论:

与Eudragit L100配制的DST-NP代表了增强乳腺癌治疗的有希望的纳米载体.
与免费达沙替尼相比,开发的纳米颗粒提供了更好的药物递送,疗效和安全性.
对DST-NP的进一步调查可能会为乳腺癌患者带来先进的治疗选择.

关键词:

癌症癌症癌症癌症在DST-NP中,它是最重要的.达沙替尼布 (Dasatinib) 是一种欧德拉吉特是什么意思欧德拉吉特是什么意思纳米颗粒是一种纳米粒子.

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