多种病变质母细胞瘤的多模式治疗 - 多中心回顾性分析
Harald Krenzlin1,2, Dragan Jankovic3, Alice Dauth3
1Department of Neurosurgery, University Medical Center, Gutenberg University Mainz, Mainz, Germany. harald.krenzlin@unimedizin-mainz.de.
Journal of neuro-oncology
|November 19, 2024
概括
多种病变质母细胞瘤 (ML) 的多式治疗可以达到与单一瘤相似的存活率. 积极的最大限度治疗,包括切除的程度,对于改善ML质母细胞瘤患者的无进展和整体存活率至关重要.
科学领域:
- 神经瘤学神经瘤学
- 手术瘤学手术瘤学
- 辐射瘤学 辐射瘤学
背景情况:
- 质母细胞瘤多重局部 (ML) 是罕见的,通常与预后不佳有关.
- 对ML质母细胞瘤的有效治疗策略对于改善患者的治疗结果至关重要.
研究的目的:
- 评估多模式治疗对多重病变质母细胞瘤 (ML) 无进展生存期 (PFS) 和总生存期 (OS) 的影响.
- 为了比较使用多式疗法治疗的ML质母细胞瘤患者的生存结果与单独病变患者的生存结果.
主要方法:
- 从两个德国神经外科部门 (2008-2020年) 进行了134名中枢神经系统WHO4级质母细胞瘤与ML患者的回顾性分析.
- 主要结局措施包括使用2021年RANO标准的切除程度 (EOR),PFS和OS.
- 倾向性得分匹配被用来比较ML患者与单独的病变瘤.
主要成果:
- 切除程度 (EOR) 是ML质母细胞瘤中PFS和OS的显著预测指标.
- 完全,近全和亚全切除与单独活检相比,显著延长了PFS和OS.
- 多模式治疗,包括放射治疗和辅助治疗 (Stupp协议),显著改善了PFS和OS.
- 倾向性得分匹配显示,ML和单一病变质母细胞瘤患者之间的PFS和OS相似 (p=0.08).
结论:
- 多式疗法可以在患有ML的患者中实现与单一损伤质母细胞瘤相比的生存率.
- 最大限度的治疗努力,包括积极的手术切除和辅助疗法,对于这个患者群体至关重要.
- 这些发现强调了密集治疗多病变质母细胞瘤的重要性.
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