一个跨部分研究的细胞因子在妇女与耐火性detrusor过度活性的对照对照对照
Kylie J Mansfield1, Zhuoran Chen2, Samantha Ognenovska2
1Graduate School of Medicine, University of Wollongong, Wollongong, NSW, 2522, Australia. kylie@uow.edu.au.
International urogynecology journal
|November 19, 2024
概括
炎症性细胞因子增加的妇女与耐火性体过活 (DO) 有关尿路感染 (UTI) 负担. 这表明炎症和尿路感染可能有助于耐火DO的发展.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 耐火性脱子过活性 (DO) 经常与尿路感染 (UTI) 和膀炎症有关.
- 了解DO中炎症标志物的作用对于开发有效治疗方法至关重要.
研究的目的:
- 为了研究与年龄相匹配的对照组相比,患有耐火性DO的妇女的尿动细胞因子度.
- 探索细胞因子水平,尿路感染史和感染标志物之间的关系.
主要方法:
- 在140名女性中 (95名耐火DO,45名对照) 用多重测定测量了27种细胞因子的尿动细胞因子水平.
- 细胞因子度与尿路感染得分,细菌性尿症,炎症和以前的尿路感染史相关.
主要成果:
- 在耐火性DO的女性中,促炎性细胞因子显著升高.
- 在DO患者中,较高的尿路感染得分与尿路细胞因子度增加相关.
- 炎症增加与更高的细胞因子水平有关,而之前的尿路感染史对没有活跃感染的DO患者的当前细胞因子水平没有影响.
结论:
- 在耐火DO中增加的促炎细胞因子与尿路感染的负担有关.
- 这些发现表明,潜在的炎症反应可能会被尿路感染加剧,可能会导致耐火性DO的发展.
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