相关实验视频
Updated: Jun 7, 2025

03:48
Restraint to Induce Stress in Mice and Rats
Published on: December 6, 2024
1.1K
侧面的管通过单氨基系统调节与压力相关的呼吸反应
Riko Mizukami1,2, Masayuki Matsumoto3,4, Tadachika Koganezawa5
1Department of Neurophysiology, Division of Biomedical Science, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
Pflugers Archiv : European journal of physiology
|November 19, 2024
概括
侧面大脑管 (LHb) 在压力时影响呼吸. 它的激活加速呼吸,主要是通过腹膜区域 (VTA) 的多巴胺系统,而血清素作为调节剂.
科学领域:
- 神经科学是一个神经科学.
- 自主神经系统的调节规则
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 心理压力会引发行为和自主变化,包括改变呼吸.
- 侧面囊 (LHb) 参与应激反应,但其在呼吸调节中的作用尚不清楚.
研究的目的:
- 为了研究侧面囊 (LHb) 在调节呼吸系统应激反应中的作用.
- 阐明神经通路和神经递质系统参与LHb介导的呼吸控制.
主要方法:
- 在麻醉的Wistar大鼠中对LHb进行电刺激.
- 多巴胺激素 (克洛沙平) 和血清激素 (梅西塞尔基德) 抗剂的全身管理.
- 使用GABAA激动剂 (肌肉醇) 抑制腹膜区域 (VTA).
主要成果:
- 激发LHb会增加呼吸频率和每分钟通风.
- 多巴胺抗剂 (克洛沙平) 抑制了LHb诱导的呼吸系统变化.
- 血清抗剂 (methysergide) 增加了呼吸频率,但降低了胸部振幅.
- 阻断VTA消除了LHb诱导的呼吸反应.
结论:
- 激活LHb加速呼吸,主要由VTA多巴胺基神经元介导.
- 血清能系统对LHb诱导的呼吸加速进行抑制调节.
- 在心理压力期间,LHb神经回路是呼吸的关键调节者.
相关概念视频
Physiology of Respiration II: Neurogenic Control of Respiration
566
The neurogenic control of respiration coordinates various neural networks and pathways to regulate breathing rate and depth, meeting the body's oxygen and carbon dioxide exchange requirements. This system adapts to physiological and environmental conditions, ensuring optimal breathing patterns.
Central Control
The brainstem is the primary site of central control, hosting respiratory centers:
Central Control
The brainstem is the primary site of central control, hosting respiratory centers:
566
Hypothalamic-Pituitary Axis
59.3K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
59.3K
Physiological Control of Respiration
2.0K
Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
2.0K
Neural Regulation of Blood Pressure
2.7K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
2.7K
Brainstem: Control Centers of Medulla
1.5K
The medulla oblongata is a crucial part of the brainstem responsible for controlling various autonomic and involuntary functions. It contains several nuclei, including the olivary, cuneate, gracile, and solitary nuclei.
Olivary Nucleus
The olivary nucleus, or inferior olivary nucleus, is located within the ventrolateral part of the medulla oblongata. It is primarily involved in motor coordination and motor learning. The olivary nucleus receives input from the spinal cord, cerebellum, and motor...
Olivary Nucleus
The olivary nucleus, or inferior olivary nucleus, is located within the ventrolateral part of the medulla oblongata. It is primarily involved in motor coordination and motor learning. The olivary nucleus receives input from the spinal cord, cerebellum, and motor...
1.5K
Neural Control of Respiration
2.2K
The neural regulation of respiration is a meticulously coordinated process primarily controlled by the respiratory centers located within the brainstem. These centers, composed of specialized neurons, transmit nerve impulses that control the contraction and relaxation of our respiratory muscles.
Respiratory Centers in the Brainstem
Two primary areas comprise the respiratory center: the medullary respiratory center in the medulla oblongata and the pontine respiratory group in the pons. The...
Respiratory Centers in the Brainstem
Two primary areas comprise the respiratory center: the medullary respiratory center in the medulla oblongata and the pontine respiratory group in the pons. The...
2.2K

