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获得的低酸性骨质疏松症:来自秘鲁推中心的病例系列 (1999-2023年)

José Paz-Ibarra^1,2, Sofía Sáenz-Bustamante³, Manuel Inostroza-Fernández⁴

¹Departamento de Endocrinología, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru. jose.paz1@unmsm.edu.pe.

Archives of osteoporosis

|November 19, 2024

概括

获得的低酸性骨质疏松症 (AHO) 诊断具有挑战性,通常与产生FGF-23.3的瘤有关. 早期瘤检测和治疗对于患者的治疗结果至关重要.

科学领域:

内分泌学在内分泌学.
代谢性骨疾病代谢性骨疾病
在瘤学瘤学.

背景情况:

获得的低酸性骨质疏松症 (AHO) 是一种罕见的骨矿化受损的疾病.
瘤诱导的骨质疏松症 (TIO) 是最常见的原因,由FGF-23的过度生产驱动.

研究的目的:

详细介绍七个秘鲁AHO病例的临床特征,诊断挑战和结果.
在资源有限的环境中突出诊断困难和治疗反应.

主要方法:

七名在1999年至2023年期间被诊断为AHO患者的回顾性审查.
收集临床数据,诊断程序,治疗方法和结果.

主要成果:

在两个病例中,瘤切除可以消除症状;在三个病例中,瘤仍未被检测到.
在大多数病例中,FGF-23水平升高;一名患者接受了burosumab.
一名患者因未解决的骨质疏松症和未检测到的瘤而死亡.

结论:

AHO诊断需要高度怀疑和生物化学确认,TIO是主要原因.
定位基瘤至关重要,但具有挑战性,特别是在发展中国家.
秘鲁有限的资源对AHO诊断和管理构成重大障碍.

关键词:

获得的低酸性骨质疏松症联邦政府财政基金23 低酸盐血症是什么情况瘤诱导的骨质疏松症

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