分析非西班牙裔黑人和白人美国人的肺癌发病率,使用多阶段致癌模型

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Sarah Skolnick¹, Pianpian Cao^1,2, Jihyoun Jeon¹

¹Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.

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概括

黑人肺癌的发病率高于白人,即使吸烟率较低. 非吸烟因素在很大程度上导致了这些差异,突出了针对种族特定的预防策略的需要.

科学领域:

流行病学流行病学
致癌的发生是致癌的产生.
公共卫生公共卫生

背景情况:

肺癌发病率表现出跨种族/族群和性别的复杂,矛盾的模式.
非西班牙裔黑人 (NHB) 男性的肺癌发病率高于非西班牙裔白人 (NHW) 男性,尽管吸烟频率较低.
尽管吸烟率较低,但NHB女性的肺癌发病率与NHW女性相似.

研究的目的:

用多阶段致癌模型研究吸烟对NHB和NHW个体肺癌发病率的影响.
在多民族队列研究 (MEC) 中,根据种族/种族和性别分析肺癌风险因素的差异.

主要方法:

采用双阶段克隆扩张 (TSCE) 模型来分析吸烟对肺瘤启动,促进和恶性转化的影响.
使用最大概率方法来估计模型参数,并评估根据种族/种族,性别和吸烟史的变化.
在MEC队列中比较NHB和NHW成年人.

主要成果:

吸烟显著增加了瘤的推广和恶性转化,但不是启动.
种族/种族和性别影响了吸烟和非吸烟相关的致癌症.
与NHW个体相比,NHB个体表现出更高的非吸烟相关启动和恶性转化,但促进率较低.

结论:

虽然吸烟是一个关键因素,但与非吸烟相关的背景风险显著导致肺癌中观察到的种族/种族差异.
开发的TSCE模型提供了对种族/种族特异性肺癌自然史的见解.
调查结果将为针对性预防干预提供信息,以解决美国肺癌结果和种族差异.

关键词:

黑人/非洲裔美国人.不平等的差异差异的差异肺癌是一种肺癌.模拟模型的模拟模型.

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