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乳酸菌 (Lactobacillus murinus) 通过促进L-氨酸的合成来减轻胰岛素抵抗

Jianglan Long¹, Zhe Shi¹, Zenghui Miao¹

¹Beijing Institute of Clinical Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Journal of endocrinological investigation

|November 19, 2024

概括

乳酸菌补充剂通过增强脂肪酸氧化和减少葡萄糖的产生来改善胰岛素抵抗. 这种由L-氨酸介导的益生菌显示出对2型糖尿病管理的潜力.

科学领域:

微生物学和免疫学
代谢障碍代谢障碍代谢障碍
肠道微生物组研究研究

背景情况:

胰岛素抵抗是2型糖尿病的标志,需要新的治疗策略.
益生菌越来越多地被研究其代谢健康益处.
乳酸菌 (Lactobacillus murinus) 是一种候选益生菌,对新陈代谢调节有未知的影响.

研究的目的:

研究Lactobacillus murinus在改善胰岛素耐药性的有效性.
阐明L. murinus发挥其作用的潜在分子机制.
为了确定参与L. murinus介导的代谢改善的关键代谢物.

主要方法:

利用胰岛素抵抗动物模型进行为期六周的治疗研究.
在实验室内服用甲福明,以评估L. murinus的生长和代谢物生产.
分析了血清代谢物,并评估了L-氨酸对胰岛素耐药性的影响.

主要成果:

L. murinus减少了体重增加,食后血糖 (PBG),改善了葡萄糖耐受性 (IGT) 和胰岛素抵抗.
L. murinus调节炎症标志物,增加IL-10并减少IL-1β,IL-6和TNF-α.
L. murinus促进脂肪酸氧化 (CPT1表达) 并抑制葡萄糖生成 (PCK和G6Pase表达).
通过L. murinus识别和升级的关键代谢物L-citrulline模仿了这些对体重,葡萄糖代谢,炎症和基因表达的有益影响.

结论:

乳酸菌 (Lactobacillus murinus) 通过通过L-氨酸介导的脂肪酸氧化增强和抑制葡萄糖生成来缓解胰岛素抵抗.
用L. murinus补充剂为管理与胰岛素抵抗相关的2型糖尿病提供了一个有希望的治疗途径.

关键词:

牛乳杆菌 (Lactobacillus murinus) 是一种植物.葡萄糖耐受性受损的情况.胰岛素耐药性胰岛素耐药性是一种这是一种L-氨酸.益生菌是一种益生菌.

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