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在接受试管婴儿/ICSI周期的韩国不孕症患者中,母体MTHFR多态和胚胎结果之间的关联
Yoo Ra Ko1, Tae Hyung Kim2, Eum Jin Hee2
1Department of Obstetrics and Gynecology, Gangnam CHA Infertility Center, CHA University School of Medicine, Seoul, Korea.
母亲的MTHFR基因变异会影响试管婴儿的结果. MTHFR 677TT基因型显示较低的卵细胞成熟率,而像MTHFR 677CT/1298AA这样的组合基因型改善了韩国不育患者的良好质量的胚胎率.
科学领域:
- 生殖医学 生殖医学
- 遗传学 是一个遗传学.
- 叶酸新陈代谢 叶酸新陈代谢
背景情况:
- 甲基基叶酸减少酶 (MTHFR) 在叶酸代谢中起着至关重要的作用,对于DNA合成和细胞生长至关重要.
- 母亲MTHFR多态和辅助生殖技术结果之间的关联尚未完全理解,需要进一步研究.
研究的目的:
- 调查韩国不育患者体外受精/细胞内精子注射 (IVF/ICSI) 周期中母体MTHFR多形态对胚胎结果的影响.
主要方法:
- 一项回顾性队列研究分析了来自173名接受MTHFR基因型定型的女性的301次试管婴儿/ICSI周期.
- 包括ANOVA和Chi-square测试在内的统计分析被用来比较基于MTHFR基因型的胚胎学结果.
主要成果:
- 卵细胞成熟率因MTHFR677的基因型而异 (677CC的80.0%,677CT的75.0%,677TT的71.4%).
- 与677CC和677TT基因型相比,MTHFR 677CT基因型显示出更高的优质胚胎 (GQE) 率.
- 组合的MTHFR基因型,如677CC/1298CC,677CT/1298AA和677CT/1298AC,与最高的GQE率有关.
结论:
- 与较低的酶活性相关的MTHFR 677TT基因型与减少的卵细胞成熟率相关.
- 特定的组合MTHFR基因型显示出改善的GQE率,这表明在IVF成功中可能发挥作用.
- 不同的MTHFR基因型之间没有观察到可移植胚胎率的显著差异.
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