儿科性直肠炎的长期病程和预后因素:一个多中心队列研究
Ayako Miyazawa1, Ryusuke Nambu1, Hirotaka Shimizu2
1Division of Gastroenterology and Hepatology, Saitama Children's Medical Center, 1-2, Shintoshin, Chuo-ku, Saitama City, Saitama 330-8777, Japan.
Inflammatory bowel diseases
|November 19, 2024
概括
儿童的耐药性性直肠炎 (UP) 通常需要免疫抑制治疗,尽管初始的5-ASA治疗. 由于儿科UP患者的疾病过程变化,密切监测至关重要.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 炎症性肠道疾病研究研究
- 临床儿科 临床儿科
背景情况:
- 儿童的性直肠炎 (UP) 通常是轻微的,但有些病例涉及近位疾病延伸,需要免疫抑制治疗.
- 在多中心队列中研究了耐火儿科UP的临床特征和结果.
研究的目的:
- 为了阐明儿童耐火性性直肠炎的自然史.
- 确定预测儿童UP免疫抑制治疗需要的因素.
主要方法:
- 来自10个儿科炎性肠病中心 (2013-2022) 的数据的回顾性分析.
- 对接受免疫抑制剂/生物药物治疗的患者与单一治疗中使用5-氨基酸 (5-ASA) 的患者进行比较.
- 使用了儿科性结肠炎活动指数和内镜评估.
主要成果:
- 51%的患者经历了疾病延伸超出脏曲.
- 37%的人需要免疫抑制治疗,其中18%的人接受了生物药物治疗.
- 持续临床缓解的时间 (>3个月) 预测了对生物制剂的需求.
结论:
- 5 - 氨基酸 (5-ASA) 假药是儿科UP的常见初始治疗方法,但符合性较差.
- 显著比例 (37%) 的儿科UP患者最终需要免疫抑制剂或生物药物.
- 个性化治疗调整和密切跟踪对于管理儿科UP是必不可少的,因为其临床过程是可变的.
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