发育规划:羊在怀孕前和怀孕期间接触生物固体对后代的卵巢动态†
Katherine M Halloran1, Yiran Zhou1, Michelle Bellingham2
1Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Biology of reproduction
|November 19, 2024
概括
对生物固体的发育暴露加速了幼羊的卵巢储备耗尽,但对成年羊的影响正常化. 这表明,近青春期的荷尔蒙变化可能会影响环境化学物质对卵巢衰老的影响.
科学领域:
- 生殖生物学 生殖生物学
- 环境毒理学环境毒理学
- 卵巢生理学 卵巢生理学
背景情况:
- 环境中的化学物质破坏了卵巢储备,加速了卵巢的衰老.
- 生物固体代表了环境化学物质的真实生活混合物.
- 发育期暴露于生物固体对后代卵巢储备耗尽的影响尚不清楚.
研究的目的:
- 调查发育期暴露于生物固体对卵巢储备耗尽在绵羊后代的累积影响.
- 评估生物固体对卵泡密度,激活率和抗穆勒尔激素表达的影响.
主要方法:
- 从暴露于生物固体或对照牧场的母羊产生的幼 (9.5周) 和成年 (2.5岁) 绵羊 (F1代) 采集了卵巢.
- 用免疫组织化学分析了毛囊密度,激活率和抗穆勒尔激素表达.
主要成果:
- 暴露于生物固体的幼羊表现出卵泡激活率的增加和原始卵泡密度的减少.
- 卵巢储备和激活率在对照群和暴露于生物固体的成年羊之间是相似的.
- 在暴露于生物固体的青少年绵羊中,抗米勒尔激素阳性 antral 毛囊密度较低,但在成年人中表达倾向于更高.
结论:
- 对生物固体的发育性暴露对卵巢储备在青春期具有有害影响,其特点是卵泡激活加速.
- 这些效应似乎在成年后正常化,这表明周围青春期荷尔蒙转变的作用.
- 研究结果支持这样一个假设:发育期暴露于生物固体等环境化学混合物,可以改变卵巢储备的动态.
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