斯蒂格马斯托醇及其在脂质体中封装的 Ester:特征,稳定性和衍生物的形成
Magdalena Rudzińska1, Katarzyna Cieślik-Boczula2, Anna Grygier1
1Faculty of Food Science and Nutrition, Poznań University of Life Sciences, Wojska Polskiego 28, 60-637 Poznań, Poland.
Food chemistry
|November 19, 2024
概括
封装着标志醇衍生物的脂质体在热下表现出不同的稳定性. 斯蒂格马斯特酸脂质体表现出最佳的热稳定性,这对于制药应用至关重要.
科学领域:
- 基于脂质的药物输送系统
- 植物醇及其衍生物.
- 热稳定性评估热稳定性的评估.
背景情况:
- 双基酸胆 (DPPC) 脂质体被广泛用于药物输送.
- 植物醇如树脂醇及其 Ester (酸,酸) 由于其治疗潜力而引起人们的兴趣.
- 了解封装化合物的热稳定性对于配方开发和储存至关重要.
研究的目的:
- 准备和表征DPPC脂质体封装自由标志素 (ST),标志素胺基酸 (ME) 和标志素酸 (OE).
- 评估这些封装植物在60°C和180°C的热降解和衍生物的形成.
- 评估植物醇结构对热应力下脂质体稳定性的影响.
主要方法:
- 使用DPPC制备脂质体.
- 在脂质体内封装ST,ME和OE.
- 通过传输电子显微镜 (TEM),FT-IR光谱,泽塔电位和水力动力直径进行表征.
- 在60°C和180°C的热应力测试.
- 植物降解和氧植物 (SOP) 形成的量化.
主要成果:
- 证实了DPPC脂质体与封装植物的成功制备.
- ST脂质体是最小的;ME和OE脂质体的大小相似.
- 降解因结构而异:在60°C时,ST (11%)
- 在180°C时发生显著的氧化素 (SOP) 形成,特别是在ST和ME脂质体中.
结论:
- 脂质体封装提供了一种提供植物衍生物的方法.
- 植物醇的结构差异显著影响它们在脂质体内的热稳定性.
- 与免费的斯蒂格马斯特和斯蒂格马斯特胺酸相比,斯蒂格马斯特酸显示出优越的热稳定性,使其成为热敏应用的有希望的候选者.
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