简要报告:是否应该重新评估以前的癌症病史,以排除参与临床试验的可能性?
Oluwaseun Ayoade1, Maureen E Canavan2, Giorgio Caturegli1
1Department of Thoracic Surgery, Yale School of Medicine, New Haven, CT, Unites States.
Lung cancer (Amsterdam, Netherlands)
|November 19, 2024
概括
免疫疗法可以改善非小细胞肺癌 (NSCLC) 患者的存活率,无论他们是否有癌症史. 将癌症幸存者纳入临床试验对于个性化治疗策略至关重要.
科学领域:
- 在瘤学瘤学.
- 临床试验 临床试验
- 癌症的生存率 癌症的生存率
背景情况:
- 从临床试验中排除有先前癌症 (PC) 病史的患者可能会限制概括性.
- 调查PC病史对非小细胞肺癌 (NSCLC) 免疫治疗有效性的影响对于现实应用至关重要.
研究的目的:
- 创建一个现实世界的代理最近的免疫疗法试验在第三阶段和第四阶段NSCLC.
- 了解接受免疫治疗的患者先前癌症史的相关性.
主要方法:
- 利用国家癌症数据库获取患者数据 (2017-2020年).
- 根据先前的癌症病史对患者进行分层,并使用倾向匹配.
- 使用Kaplan-Meier和Cox比例危险模型分析了整体存活率.
主要成果:
- 免疫疗法补充改善了第三阶段NSCLC患者的存活率,有或没有癌症史 (HR:0.65-0.69).
- 免疫疗法补充也改善了第四阶段NSCLC患者的存活率,有或没有先前的癌症史 (HR:0.75-0.78).
结论:
- 现实世界的数据证实了免疫治疗的优越性,而不管先前的癌症史.
- 应将癌症幸存者纳入试验,以便根据个体属性进行个性化治疗.
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