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泌尿器 dickkopff-3作为术后急性损伤在重症监护室的一个预测因素

Yao Sun¹, Zengli Xiao¹, Huiying Zhao¹

¹Department of Critical Care Medicine, Peking University People's Hospital, No.11 Xizhimen South Street, Xicheng District, Beijing 100044, PR China.

The American journal of the medical sciences

|November 19, 2024

概括

尿路头相关蛋白3 (DKK3) 可以预测非心脏手术后的急性损伤 (AKI). 一个使用尿液DKK3,eGFR,cystatin C和SOFA分数的新型诺摩图准确地预测了ICU患者的AKI风险.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
关键护理医学关键护理医学
手术并发症手术并发症

背景情况:

急性损伤 (AKI) 是手术后的严重并发症,严重恶化患者的预后.
泌尿头相关蛋白3 (DKK3) 已成为预测心脏手术患者AKI的潜在生物标志物.

研究的目的:

评估尿道DKK3在非心脏外科手术中的术后AKI的预测能力.
在非心脏手术后七天内开发AKI的临床预测模型.

主要方法:

收集了166名非心脏手术后的ICU患者的人口,临床和实验室数据.
在ICU入院时评估尿液DKK3 (uDKK3/uCr),囊素C和SOFA得分.
利用单变量,多变量和LASSO分析来识别AKI预测因子并构建一个名ogram.

主要成果:

在28.3%的患者 (47/166) 中发生了术后的AKI.
拉索分析发现了四个独立的预测因子:手术前的eGFR,囊素C,DUKK3/uCr和SOFA分数.
开发的诺米图实现了0.868的AUC,证明了良好的预测性能.

结论:

尿液DKK3/肌素是非心脏手术ICU患者术后AKI的独立预测因子.
整合DUKK3/uCr,手术前eGFR,cystatin C和SOFA分数的诺米图为AKI预测提供了高准确度.

关键词:

头相关的蛋白质 3 头相关的蛋白质这个名字叫做Nomogram.手术后的急性损伤.预测者预测者

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