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探索材料选择对热挤出效果的影响
Devesh U Kapoor1, Devendra J Vaishnav2, Rahul Garg3
1Dr. Dayaram Patel Pharmacy College, Bardoli 394601, Gujarat, India.
International journal of pharmaceutics
|November 19, 2024
概括
热挤出 (HME) 提高了水溶性较差的药物的药物溶性和生物可用性. 精心选择聚合物和增塑剂对于优化HME配方和改善治疗结果至关重要.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 热挤出 (HME) 是提高水溶性差的药物的可溶性和生物利用性的关键技术.
- 对于开发先进的药物输送系统,HME提供了一种多功能方法.
研究的目的:
- 审查HME在制药配方中的基本原则和应用.
- 分析聚合物和塑化剂在HME过程中的作用及其对药物释放和稳定性的影响.
主要方法:
- 综合审查与HME相关的科学文献和专利.
- 对HME配方的聚合物和可塑剂选择的分析.
- 对聚合物-塑化剂系统的玻璃过渡温度 (Tg) 预测模型的讨论.
主要成果:
- 确定了HME中使用的关键聚合物 (例如HPMC,EC,HPC,PVP) 和增塑剂 (例如三乙烯,PPG,甘油,醇)
- 强调了塑化剂在降低Tg方面的重要性,以提高加工能力.
- 通过HME.提供了关于可溶性和生物利用性增强机制的见解.
结论:
- 精细的材料选择对于成功的HME应用至关重要.
- HME显著提高了制药制造和药物输送效率.
- 该综述为优化HME策略和了解其商业应用提供了全面的资源.
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