肝细胞癌系统治疗更新:从早期到高级阶段
Wei Teng1, Tai-Chi Wu2, Shi-Ming Lin3
1Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Liver Research Center, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
Biomedical journal
|November 19, 2024
概括
系统性疗法,包括免疫检查点抑制剂和氨酸激酶抑制剂,正在推进肝细胞癌 (HCC) 治疗. 研究正在将它们的使用扩展到早期阶段,并探索新的T细胞重定向策略.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 免疫疗法是一种免疫疗法.
背景情况:
- 肝细胞癌 (HCC) 是全球癌症死亡的主要原因.
- 系统疗法的近期进展改善了中期和高级HCC的治疗结果.
- 目前的全身治疗主要用于晚期,对早期HCC的证据有限,特别是治疗后的复发.
研究的目的:
- 审查HCC系统治疗的最新进展.
- 总结关于一线和二线治疗,新辅助/辅助设置以及与局部区域疗法的组合的发现.
- 突出正在进行的试验和HCC的所有阶段的新目标.
主要方法:
- 对HCC的全身疗法的文献综述.
- 对多重氨酸激酶抑制剂 (mTKI) 和免疫检查点抑制剂 (ICI) 的临床试验数据的分析.
- 评估T细胞重定向策略,包括双特异性抗体和CAR T细胞.
主要成果:
- 结合疗法 (ICI + 抗血管原或双 ICI) 现在是高级 HCC 的标准.
- 系统疗法越来越多地被认为是早期的阶段,以及作为新辅助/辅助治疗.
- T细胞重定向策略正在彻底改变HCC治疗模式.
结论:
- 系统疗法正在扩展到超出先进的HCC,为早期阶段提供新的选择.
- 新的目标和组合策略正在调查中.
- 对瘤屏障机制的进一步研究对于未来的进展至关重要.
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