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使用液体染色学-并联质谱法确定牛肉中的荷尔蒙生长促进剂

Mary Mosburg¹, Yajing Li¹, Emily Helmes¹

¹KL Maddy Equine Analytical Chemistry Laboratory, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.

Drug testing and analysis

|November 19, 2024

概括

一种新方法可以检测肉类中的激素生长促进剂 (HGPs),确保食品安全. 这种对零售肉制品中HGP的分析对于公共卫生监测至关重要.

科学领域:

食品科学食品科学食品科学
分析化学分析化学
毒理学毒理学毒理学

背景情况:

激素增长促进剂 (HGPs) 在美国用于牛生产,以提高生长和肉质.
人们担心肉类中的残留HGP以及消费对健康的潜在不良影响,包括癌症.
准确的检测方法对于评估人口在肉类中的HGP暴露至关重要.

研究的目的:

开发和验证一种敏感和选择性的方法,用于检测零售肉片中的多个HGP.
为了能够准确评估肉制品消费者对HGP暴露的情况.

主要方法:

液体染色学-并联质谱学 (LC-MS/MS) 用于HGP检测.
使用高pH溶液的液体-液体提取方法,需要更少的肉质量.
化被用作移动相添加剂,消除了衍生物化的需要.

主要成果:

该方法成功检测出低水平 (0.11.0 ng/g) 的包括雌激素,,孕激素和 trenbolone 在内的 HGP.
这种方法表现出良好的染色学性能,灵敏度,准确性和精度.
样品的准备工作简化了,与现有方法相比,需要少得多的肉类.

结论:

一种经过验证的LC-MS/MS方法提供了对零售肉类中HGP的敏感和选择性检测.
这种方法有助于有效监测HGP残留物,有助于食品安全和公共卫生.
精简的样本制备提高了对肉制品中HGP的常规分析的效率.

关键词:

这里是牛群.激素增长促进剂激素增长促进剂液态染色学质谱学质谱学类固醇类固醇是什么

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