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Giacomo Koch^1,2, Daniele Altomare³, Alberto Benussi⁴

¹Experimental Neuropsychophysiology Lab, Santa Lucia Foundation IRCCS, 00179 Rome, Italy.

Brain : a journal of neurology

|November 19, 2024

概括

非侵入性脑刺激显示出改善阿尔茨海默病患者认知功能的前景. 通过调节关键大脑网络,诸如重复性跨脑磁性刺激等技术可以增强大脑可塑性和认知性能.

科学领域:

神经科学是一个神经科学.
神经学神经学
认知科学认知科学

背景情况:

认知障碍,特别是阿尔茨海默病,在临床神经科学中是一个重大挑战.
非侵入性脑刺激 (NIBS) 正成为一种有前途的治疗策略,用于认知增强.
了解大脑连接的进步促进了针对性NIBS协议的开发.

研究的目的:

审查有效的非侵入性脑刺激方案,以增强阿尔茨海默氏症患者的认知功能.
探索NIBS对认知表现和脑病理标志物的影响.
讨论调节特定大脑网络在NIBS疗效中的作用.

主要方法:

关于各种非侵入性脑刺激技术的最新研究的综述.
对阿尔茨海默病模型和患者的临床前和临床数据的分析.
专注于包括重复性横磁性刺激 (rTMS),横直流刺激 (tDCS) 等协议.

主要成果:

增强大脑可塑性的超刺激方法对认知功能产生有益影响.
在不同认知障碍严重程度的临床前模型和临床研究中报告了积极的结果.
在阿尔茨海默病患者中提高认知功能的有效性或减缓认知衰退.

结论:

非侵入性脑刺激方案,特别是那些针对前额-双肩和默认模式网络的方案,在阿尔茨海默病中显示出有效性.
特定大脑网络的调制是NIBS有益的认知效应的基础.
对刺激参数的个性化具有优化未来NIBS应用的潜力.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.通过光生物调节.跨骨交替电流刺激通过骨进行直流刺激.跨骨聚焦超声波超声波的使用方法跨的磁性刺激

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