糖类和制造方法如何影响小儿友好型或乳腺膜的可口性 甲化的甲化
Konstantina Chachlioutaki1, Xiunan Li2, Savvas Koltsakidis3
1Department of Pharmacy, Division of Pharmaceutical Technology, Aristotle University of Thessaloniki, Thessaloniki, Greece; Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Thessaloniki, Greece.
Carbohydrate polymers
|November 19, 2024
概括
开发出以糖为基础的菌膜,通过掩盖苦味,提供易于管理的剂量形式,改善了儿童的药物坚持. 这些电影显示了作为传统儿科药物的替代品的希望.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 儿科医学 儿科医学
背景情况:
- 儿童的药物坚持往往是很差的,因为不好吃的药物和难以吞的配方.
- 口腔粘膜提供了一个有前途的替代方案,增强了儿童的口感和易于管理.
- 基于糖的电影可以改善味道和患者的接受度,解决儿科药物输送中的关键挑战.
研究的目的:
- 开发和评估基于糖的口腔粘膜,以改善儿科患者的口味性和粘附性.
- 为了评估含有普罗马зин化的电和3D打印的普鲁兰基薄膜的口味掩饰效果.
- 调查这些新型药物输送系统的体外和体内可接受性.
主要方法:
- 开发了电和3D打印的oromucosal膜,使用pullulan和甜味剂为甲化 (CHZ).
- 使用电子舌头在体外评估味道掩盖功效.
- 在人体志愿者体内评估体内可接受性.
主要成果:
- 用3D打印的片显示,用糖,糖和异盐对苦CHZ的味道有显著的抑制.
- 在体内研究表明,在志愿者中,基于糖的3D打印电影的接受度很高.
- 电膜获得了中立的可接受性评级,可能是由于配方不熟悉.
结论:
- 基于糖的3D打印的oromucosal膜显示了有效的口味掩饰和儿童高接受度的潜力.
- 这些片代表了对儿科药物的传统固体口服剂型的可行的替代方案.
- 进一步优化可以提高用于儿科药物输送的电和3D打印膜的效用.
相关概念视频
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