循环炎症蛋白在1型和2型糖尿病中升高,并与并发症相关
Julia I P van Heck1, Mandala Ajie1, Leo A B Joosten1,2
1Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.
Diabetes, obesity & metabolism
|November 19, 2024
概括
无论是1型还是2型糖尿病,都显示炎症标志物增加. 虽然2型糖尿病具有更明显的炎症反应,但两者都有与糖尿病并发症相关的类似途径.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 低度炎症与2型糖尿病的血管并发症有关.
- 1型糖尿病的全身炎症及其与并发症的联系尚不清楚.
- 这项研究调查了1型和2型糖尿病的系统性炎症.
研究的目的:
- 为了比较1型糖尿病,2型糖尿病和健康对照的循环炎症蛋白质.
- 为了确定炎症蛋白和糖尿病特征 (HbA1c,BMI) 之间的关联.
- 探索炎症蛋白与糖尿病相关并发症 (包括病和心血管疾病) 之间的联系.
主要方法:
- 使用向蛋白质组学方法,分析了233名1型糖尿病患者,387名2型糖尿病患者和150名对照患者的血.
- 使用Olink平台量化了高灵敏度C反应蛋白 (hs-CRP) 和92种其他炎症蛋白.
- 进行了统计分析 (FDR < 0.05),以确定显著差异和关联.
主要成果:
- 与对照人群相比,1型糖尿病中有41种炎症蛋白升高,2型糖尿病中有64种升高.
- 在1型糖尿病中,HbA1c水平与21种炎症蛋白相关;在2型糖尿病中,BMI与26种相关.
- 与并发症,特别是病相关的蛋白质在两种糖尿病类型中都相似; FlT3L和EN-RAGE与2型糖尿病中的心血管疾病有关.
结论:
- 1型和2型糖尿病都表现出循环炎症蛋白的增加,在2型糖尿病中观察到更大的增加.
- 研究结果表明,每个类型的糖尿病都有不同的炎症驱动因素,但并发症发展的途径是共同的.
- 这项研究强调了系统性炎症在糖尿病病理生理学及其并发症中的作用.
相关概念视频
Pathophysiology of Diabetes
868
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
868
Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
Diabetes: Symptoms, Diagnosis, and Complications
506
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
506
Diabetes Mellitus: Overview and Type I Subtype
2.4K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.4K
Psychoneuroimmunology: Diabetes and Cancer
24
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
24
Carbohydrate Metabolism
10.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.8K


