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结构性脑成像自闭症谱系障碍的生物标志物

David G Amaral¹, Derek Sayre Andrews², Christine Wu Nordahl²

¹The Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and the Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine, University of California Davis, Sacramento, CA, USA. dgamaral@ucdavis.edu.

Advances in neurobiology

|November 19, 2024

概括

对自闭症大脑的磁共振成像 (MRI) 研究已经探索了生物预测因素和改变的大脑系统. 较少的研究集中在与自闭症治疗相关的脑部变化上,限制了MRI.

科学领域:

神经成像是一种神经成像.
自闭症谱系障碍研究研究

背景情况:

自20世纪90年代以来,广泛的研究已经利用磁共振成像 (MRI) 来研究自闭症大脑.
研究旨在识别自闭症诊断的早期生物标志物,并绘制自闭症患者改变的大脑系统的地图.

研究的目的:

审查脑成像,特别是MRI作为自闭症生物标志物的实用性.
讨论神经成像在识别自闭症亚型和评估治疗干预的应用.

主要方法:

关于自闭症磁共振成像的成千上万篇发表报告的审查.
对专注于生物预测因素,大脑系统变化和亚型识别的研究进行分析.
对研究治疗干预的神经成像相关的研究进行审查.

主要成果:

成千上万的MRI研究已经调查了自闭症,专注于早期预测因素和大脑变化.
新兴的研究探索使用脑成像模式来定义自闭症亚型.
有限的研究专门确定了与自闭症治疗干预相关的脑部变化.

结论:

大脑成像,特别是MRI,已被广泛用于了解自闭症的神经生物学.
虽然它对于识别预测因素和改变系统是有用的,但它作为确定的自闭症生物标志物的作用仍在不断发展.
需要进一步的研究来确定神经成像在跟踪治疗反应和指导治疗策略中的有用性.

关键词:

自闭症自闭症自闭症扩大大脑的大脑额外轴流体额外轴流体磁共振成像 (MRI) 是一种磁共振成像.

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