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认知控制,反应抑制,侵略性,冲动性和暴力的生物标志物

Matthew J Hoptman^1,2, Ragy R Girgis^3,4, Daniel C Javitt^5,6

¹Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA.

Advances in neurobiology

|November 19, 2024

概括

认知控制缺陷与神经精神疾病有关. 研究探讨了用于目标选择,响应选择和绩效监测的生物标志物,这对于理解冲动性和攻击性至关重要.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
认知科学认知科学

背景情况:

认知控制的缺陷与各种神经精神疾病有关.
认知控制,包括目标选择,响应选择和性能监测,是关键的研究领域结构 (RDoC).
与侵略性和自杀性相关的冲动性与紧迫性和令人丧的不奖励有关,但缺乏经过验证的生物标志物.

研究的目的:

审查认知控制在神经精神疾病中的作用.
讨论使用fMRI和ERP的认知控制子域的候选生物标志物.
探索潜在的生物标志物开发紧急性和侵略性.

主要方法:

对认知控制任务 (AX-CPT,Go/NoGo,SSrt) 的现有文献的审查.
检查神经成像 (fMRI) 和电生理学 (ERP) 方法.
冲动性尺度 (UPPS-P) 和行为范式 (PSAP) 的分析.

主要成果:

fMRI和ERP研究为认知控制机制提供了候选生物标志物.
冲动性,特别是紧迫性和令人丧的没有奖励,与侵略性和自杀倾向有关.
目前,没有经过验证的生物标志物用于紧急性或攻击性.

结论:

认知控制研究为了解神经精神疾病提供了一个框架.
翻译性研究可以利用神经成像和电生理学数据来开发生物标志物.
需要进一步的研究来建立紧急性和侵略性的预测生物标志物.

关键词:

认知控制认知控制与事件相关的潜力与事件相关的潜力执行处理执行处理.响应抑制反应的抑制.功能磁力共振成像 (fMRI) 是一种

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