甲氨酸对认知表现和随后的睡眠产生剂量反应效应
Carissa L Gardiner1,2, Jonathon Weakley3,4,5, Josh Leota6,7
1School of Behavioural and Health Sciences, Australian Catholic University, Brisbane, Australia.
Scientific reports
|November 20, 2024
概括
泰克林可以提高第二天早上的认知功能,特别是减少失误,而不会显著影响睡眠. 这种兴奋剂显示出作为咖啡因用于认知支持的替代品的承诺.
科学领域:
- 营养神经科学 营养神经科学
- 认知表现 认知表现
- 睡眠科学 睡眠科学
背景情况:
- 像咖啡因这样的精神兴奋剂可以抵消睡眠不足导致的认知缺陷.
- 咖啡因的不良影响,包括睡眠障碍,需要探索替代品.
- 泰克林被研究为一种潜在的认知增强剂,而不会影响睡眠.
研究的目的:
- 检查阿克林剂量和时间对认知表现和睡眠的影响.
- 为了比较低 (100毫克) 和高 (400毫克) 的theacrine剂量在睡觉前不同时间服用.
主要方法:
- 人类参与者在早上,下午或晚上消耗theacrine (100毫克或400毫克).
- 第二天早上使用精神运动警觉任务 (PVT) 评估认知表现.
- 监测睡眠参数以评估theacrine对睡眠质量的影响.
主要成果:
- 泰克林并没有显著影响整体睡眠质量.
- 在睡前8小时内摄入高剂量 (400毫克) 的theacrine可以减少PVT的失效.
- 没有观察到对反应时间的显著影响,并且只注意到对睡眠效率和睡眠开始后醒来的轻微,无意义的影响.
结论:
- 的消费,特别是在睡前8小时内服用400毫克的剂量,可能会改善第二天早上认知表现的特定方面.
- 泰克林似乎对夜间睡眠质量的影响很小.
- 需要进一步的研究,以充分了解theacrine的认知和睡眠效应.
相关概念视频
Sedatives and Hypnotics Drugs: Miscellaneous Agents
146
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
146
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
98
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
98
Direct-Acting Cholinergic Agonists: Pharmacological Actions
1.2K
Direct-acting cholinergic agonists exert their pharmacological actions by mimicking the effects of acetylcholine on postsynaptic muscarinic receptors to generate parasympathetic responses. These agents elicit a range of physiological responses, including cardiovascular effects. For example, activation of muscarinic receptors induces bradycardia, decreased cardiac output, reduced peripheral resistance, and consequent hypotension. In the eye, stimulation of M3 receptors leads to smooth muscle...
1.2K
Substance Use Disorders Affecting Sleep
160
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
160
Indirect-Acting Cholinergic Agonists: Pharmacological Actions
618
Indirect-acting cholinergic agonists, also known as anticholinesterases, exert their pharmacological effects by enhancing cholinergic transmission in various body parts, including the neuromuscular junction, autonomic cholinergic synapses, and the brain.
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
618
Dose-Response Relationship: Potency and Efficacy
4.2K
The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it...
4.2K


