血液造血干细胞移植患者的心理风险因素:来自国家再接收数据库分析的见解
Qi Zhang1, Qiuyan Yu1, Qian Chen1
1Department of Hematology, Tengzhou Central People's Hospital, Tengzhou, China.
Psycho-oncology
|November 20, 2024
概括
心理社会风险因素 (PSRFs) 与血液造血干细胞移植 (HSCT) 的更差结果有关. 识别患有PSRF的患者可以改善护理并减少HSCT后的再入院.
科学领域:
- 血液学 血液学 血液学
- 移植医学 移植医学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 心理社会风险因素 (PSRF) 越来越多地被认为是不良医疗结果的重要预测因素.
- 然而,它们对造血干细胞移植 (HSCT) 结果的影响仍未得到充分研究.
研究的目的:
- 追溯评估PSRF与接受HSCT患者的住院和短期结局之间的关联.
- 为了比较不同HSCT类型的PSRF患者和没有PSRF患者之间的结果.
主要方法:
- 利用国家再接收数据库 (NRD) 来识别2011-2020年HSCT患者.
- 根据0或≥1个PSRF的存在来分层患者 (例如,精神疾病,药物滥用,低收入,无保险状态).
- 将患者分为全源HSCT (allo-HSCT) 和自身HSCT (auto-HSCT) 组,分析住院和30天再入院率.
主要成果:
- 总共有90,747名自动HSCT和26,600名合并HSCT患者被分析.
- 患有PSRFs的患者在自动HSCT和all-HSCT组中显示出明显更高的住院死亡率和30天再入院率.
- 确定PSRFs是30天再接收风险增加的实质性预测因子,这两种HSCT类型.
结论:
- 由于PSRF的存在,在alo-HSCT和自动-HSCT后,医院住院和短期结果较差.
- 在all-HSCT中,PSRF对结果的影响似乎更为明显.
- 识别患有PSRF的患者对于有针对性的干预和改善HSCT后护理至关重要.
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