[针对青少年异常性关节炎的关节功能和健康评估尺度的开发和验证]
L Y Zheng1, L Y Gao1, Y Zhang1
1Department of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Infection and Immunity, Chongqing400014, China.
Zhonghua er ke za zhi = Chinese journal of pediatrics
|November 20, 2024
概括
一个新的尺度有效地评估了青少年异常性关节炎 (JIA) 的儿童的关节功能和健康状况. 这种经过验证的工具显示出良好的可靠性和对临床变化的响应能力,有助于JIA患者管理.
科学领域:
- 类风湿病学 类风湿病学
- 儿科 儿科 儿科
- 健康 结果 研究 研究 结果
背景情况:
- 青春期异常性关节炎 (JIA) 显著影响儿童的关节功能和整体健康.
- 准确的评估工具对于监测儿童类风湿病的疾病进展和治疗疗效至关重要.
研究的目的:
- 开发和验证一个全面的关节功能和健康评估尺度,专门用于患有青少年异常性关节炎的患者.
- 评估尺度的可靠性,有效性和对儿科患者群体临床变化的响应能力.
主要方法:
- 一个多阶段的开发过程,包括文献审查,专家咨询 (德尔菲方法) 和患者访谈.
- 从260名患有JIA的儿童收集前性数据,随后进行严格的统计分析,包括可靠性,有效性和因子分析.
- 使用临床重要的最小差异 (MCID) 和与已建立的JIA结果措施的相关性来评估规模响应.
主要成果:
- 开发的尺度包括5个维度和24个项目,包括疾病活动,日常功能,疼痛和疲劳.
- 观察到出色的内部一致性 (克朗巴赫的α=0.88) 和测试重试可靠性 (r=0.84).
- 该尺度表现出与现有的JIA评估工具有很强的相关性,证实了其有效性和对临床改进的适度响应.
结论:
- 新开发的青少年无形性关节炎关节功能和健康评估尺度是一个可靠和有效的工具.
- 该尺度响应临床变化,并且实际用于评估JIA儿童的关节功能.
- 这种工具可以帮助临床医生更好地管理JIA患者并评估治疗结果.
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