运动器官肌肉质量与运动期间心脏功能之间的关联心力衰竭与保存的射出分数心力衰竭
Salaheddin M Sharif1, Joshua R Smith1, Barry A Borlaug1
1Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
European journal of heart failure
|November 20, 2024
概括
肌肉质量 (MQ) 在心力衰竭中显著降低,患有保存喷射率 (HFpEF) 患者,并且与运动期间心脏功能降低相关. 这表明MQ可能有助于评估HFpEF的运动能力.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 肌肉生理学 肌肉生理学
背景情况:
- 肌肉质量 (MQ) 是骨肌肉功能的一个关键指标.
- 在心力衰竭中,MQ和运动期间心脏功能之间的关系与保存的喷射分数 (HFpEF) 仍然不清楚.
- 了解这种关系对于管理HFpEF患者的运动能力至关重要.
研究的目的:
- 调查运动肌质质量与运动期间心脏功能在HFpEF患者之间的关联.
- 为了比较HFpEF患者和健康对照者在运动期间的MQ和心脏表现.
主要方法:
- 招募了22名HFpEF患者和23名健康对照 (CTL).
- 使用双能X射线吸收计测量身体组成 (腿筋质量百分比 - LL%).
- 进行心肺运动测试以测量峰值氧气吸收 (VO2),心脏输出 (CO),心脏输出功率 (CPO) 和平均动脉压 (MAP).
- 计算的MQ是峰值瓦特除以LL%.
主要成果:
- 与对照组相比,HFpEF患者的LL%显著降低.
- 在运动的高峰期,HFpEF患者的工作量,VO2,CO和CPO显著减少.
- 肌肉质量在HFpEF患者 (1.6 W/%) 中明显低于对照组 (2.3 W/%) (p < 0.0001).
- 在HFpEF中,MQ与CO (r=0.51),CPO (r=0.72) 和MAP (r=0.64) 正相关 (p <0.05对所有).
结论:
- 肌肉质量与HFpEF患者在峰值运动时的心脏功能密切相关.
- 这些发现表明,MQ可以作为评估HFpEF运动表现的有价值指标.
- 对MQ的进一步研究可能会为HFpEF的运动不耐受提供新的见解.
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