高血压妊娠障碍,一个未被认可的女性特异性心力衰竭风险因素?
Chahinda Ghossein-Doha1, Basky Thilaganathan2,3, Arthur Jason Vaught4
1Cardiovascular Institute, Thorax Center, Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands.
European journal of heart failure
|November 20, 2024
概括
妊娠高血压障碍 (HDP) 显著增加女性的长期心血管疾病风险. 早期查和标准化干预措施对于预防未来的心力衰竭和其他心血管并发症至关重要.
科学领域:
- 心血管医学 心血管医学
- 产科 产科 产科 产科 产科
- 生殖健康 生殖健康
背景情况:
- 怀孕涉及到显著的母体心血管适应.
- 妊娠高血压障碍 (HDP),包括妊娠前,影响近10%的怀孕.
- HDP与心肌功能受损和不良的心脏重塑有关.
研究的目的:
- 审查HDP与女性长期心血管疾病 (CVD) 风险之间的联系.
- 探索将HDP与未来心力衰竭联系在一起的机制,特别是心力衰竭与保留射出分数 (HFpEF).
- 突出需要标准化CV查和HDP后的干预协议.
主要方法:
- 关于怀孕期间母亲心血管适应的研究的文献综述.
- 对HDP患病率和长期CV结果的流行病学数据的分析.
- 讨论将HDP与心脏重塑和未来心血管疾病联系起来的病理生理机制.
主要成果:
- 患有HDP的女性表现出心脏功能受损和心脏重塑.
- HDP增加了高血压,脏疾病,失脂症和分娩后糖尿病的风险.
- 在HDP发生后的20年内,心力衰竭,慢性高血压和缺血性心脏/大脑疾病的发病率增加.
结论:
- HDP可能会增加对未来代谢和血液动力学攻击的敏感性.
- 种族差异和健康的社会决定因素影响长期的CV风险后HDP.
- 对于有HDP史的女性,需要标准化的心血管查和干预方案.
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