怀孕期间自身免疫性疾病的药物趋势及其中止的因素:基于人口的研究
Sabine Mainbourg1,2,3, Odile Sheehy1, Jessica Gorgui1
1Research Center, CHU Sainte Justine, 3175, Chemin de la Côte‑Sainte‑Catherine, Montreal, QC, H3T 1C5, Canada.
BMC pregnancy and childbirth
|November 20, 2024
概括
对自身免疫性疾病的药物使用总体上增加,但在怀孕期间下降. 近年来,药物停用率较低,这凸显了对患有自身免疫性疾病的孕妇需要更好的管理策略的需要.
科学领域:
- 生殖健康 生殖健康
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 自免疫性疾病的治疗方法已经进步,但与怀孕相关的治疗变化仍未得到充分研究.
- 了解怀孕期间的药物使用对于母亲和胎儿的健康至关重要.
研究的目的:
- 分析免疫抑制剂,免疫调节剂和在怀孕期间用于自身免疫性疾病的生物使用的时间趋势.
- 为了比较怀孕前,怀孕期间和怀孕后的药物使用情况.
- 为了确定在怀孕期间停止药物治疗的预测因素.
主要方法:
- 使用北克怀孕队列 (1998-2015) 采用12个月的怀孕前后数据.
- 包括患有特定自身免疫性疾病 (IBD,RA,SLE等) 的女性. ) 的情况.
- 使用处方数据和概括估计方程,评估药物暴露和停止使用药物.
主要成果:
- 从1998年至2014年,免疫调节剂,免疫抑制剂和生物制剂的总体使用量增加了.
- 在所有三种药物类别中,孕妇暴露显著下降.
- 之前的生物使用和晚些时候的怀孕年预测免疫抑制剂的停用;晚些时候的怀孕年预测生物的停用.
结论:
- 虽然先进的自身免疫治疗方法的整体使用量有所增加,但在怀孕期间它们的使用量有所下降.
- 近年来,有迹象表明,怀孕期间停药率下降的趋势.
- 识别影响停药的因素是优化对患有自身免疫性疾病的孕妇管理的关键.
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