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使用MACFIMS对多发性硬化症患者和健康对照患者的认知障碍进行比较:系统性审查和元分析

Amirreza Nasirzadeh¹, Mohammad Mohammadi², Melika Arab Bafrani³

¹Department of Medical-Surgical Nursing, Faculty of Nursing, Nursing Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.

|November 20, 2024

概括

认知障碍在多发性硬化症 (MS) 中很常见,会影响处理速度和记忆. 多发性硬化症认知功能的最小评估 (MACFIMS) 工具有效地识别了与健康个体相比,MS患者的这些缺陷.

科学领域:

神经科学是一个神经科学.
临床神经学临床神经学
心理学心理学心理学

背景情况:

多发性硬化症 (MS) 是一种慢性中枢神经系统自身免疫性疾病.
认知功能障碍影响超过65%的MS患者,影响日常生活.
在MS中认知障碍往往在临床上被忽视.

研究的目的:

用多发性硬化症认知功能的最小评估 (MACFIMS) 电池,评估患有多发性硬化症 (pwMS) 患者的认知功能与健康对照 (HCs) 的认知功能.
系统地审查和分析现有的研究对成人多发性硬化症患者的MACFIMS有效性.

主要方法:

按照PRISMA指南进行系统审查和元分析.
综合的数据库搜索 (科学网络,PubMed,Scopus,科克兰图书馆).
包括8项研究,包括1481个pwMS和1072个HC;使用R4.2.3.3进行数据分析.

主要成果:

与HC相比,在所有MACFIMS子测试中,pwMS的认知缺陷显著.
处理速度和工作内存是受影响最严重的领域.
较高的扩展残疾状态量表 (EDSS) 分数与较大的认知障碍相关.

结论:

MACFIMS是区分pwMS和HCs之间的认知功能的一个有效工具.
常规认知查,特别是处理速度和工作记忆,是早期MS干预的建议.
需要进一步的研究来评估MACFIMS在MS亚型和文化中的敏感性和特异性.

关键词:

认知障碍认知障碍是一种认知障碍.马克菲姆斯 (MACFIMS) 公司多发性硬化症是多发性硬化症.

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