杏仁核的广泛不对称性预测了精神分裂症患者的听觉语言幻觉
Magda L Dumitru1,2, Erik Johnsen3,4,5, Rune A Kroken3,4,5
1Department of Biological Sciences, University of Bergen, Thormøhlens Gate 53 A/B, Postboks 5006, Bergen, Norway. magda.dumitru@gmail.com.
精神分裂症幻觉与杏仁体重组有关. 增加的局部不对称性和减少的全球不对称性与幻觉严重程度相关,这表明杏仁体的全球重组.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 听觉语言幻觉 (AVH) 在精神分裂症中很常见,通常涉及负面情绪.
- 大脑不对称性与精神分裂症有关,但它们在杏仁体中的作用,对于情绪处理至关重要,关于AVH仍然不清楚.
研究的目的:
- 调查杏仁体不对称性和精神分裂症听觉语言幻觉的严重程度之间的关系.
- 探索新型不对称生物标志物在预测幻觉严重性的有用性.
主要方法:
- 两个不对称生物标志物,距离指数 (全球) 和修订的横向指数 (本地),应用于杏仁核体积.
- 随机森林回归模型用于分析71名精神分裂症患者和71名年龄匹配对照的数据.
主要成果:
- 这两种不对称生物标志物都成功预测了幻觉的严重程度.
- 幻觉严重程度随着局部杏仁体不对称性增加和全球不对称性减少而增加.
结论:
- 研究结果表明,在患有AVH的精神分裂症患者中,杏仁体的全球重组.
- 杏仁核体积随着幻觉严重程度的增加而变得比例更相似.
- 识别特定的大脑结构不对称可能有助于监测精神分裂症的进展和治疗结果.
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