胰岛素抵抗替代指数和勃起功能障碍的关联:系统性审查和元分析
Sayeh Jalali1, Negar Zareshahi1, Amir Hossein Behnoush1
1School of Medicine, Tehran University of Medical Sciences, Tehran Province, District 6, Pour Sina St, P94V+8MF, TehranTehran, Iran.
Reproductive biology and endocrinology : RB&E
|November 20, 2024
概括
胰岛素抵抗 (IR) 与勃起功能障碍 (ED) 有关. 像HOMA-IR,TyG和VAI这样的指数在ED男性中显示出更高的水平,但由于不一致的准确性,它们对ED发病率的预测值有限.
科学领域:
- 内分泌学 在内分泌学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 代谢综合征是代谢综合征的一种.
背景情况:
- 勃起功能障碍 (ED) 与胰岛素抵抗 (IR) 有关.
- 为了量化IR,使用了几个替代指数.
- 在IR指数和ED之间的关系需要进一步澄清.
研究的目的:
- 系统地审查和元分析IR指数与ED发病率和严重程度之间的关联.
- 为了评估ED的IR指数的诊断准确性.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,Scopus) 中进行全面的文献搜索.
- 来自17项涉及3810名ED患者和8252名对照患者的研究数据的元分析.
- 使用纽卡斯尔-太华尺度 (NOS) 进行偏差风险评估.
- 敏感性分析和元回归来解决异质性问题.
主要成果:
- 患有ED的男性表现出显著更高的胰岛素抵抗 (HOMA-IR),三糖-葡萄糖指数 (TyG) 和内脏肥胖指数 (VAI) 的水平.
- 在HOMA-IR或TyG与ED的几率之间没有发现显著的相关性.
- 增加的VAI与更严重的ED有关,但诊断准确性在各指数中各不相同.
结论:
- 通过HOMA-IR,TyG和VAI表示的胰岛素耐药性与勃起功能障碍有显著联系.
- 这些指数对ED的预测效用受到显著的异质性和不一致的诊断精度的限制.
- 进一步的研究对于确定IR指数在治疗ED方面的临床实用性至关重要.
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