儿童急性胰腺炎的止痛疗法:一个覆盖范围的系统性审查
James Lucocq1, Nejo Joseph2, Cecilie Sigaard Knoph3
1Department of General Surgery, NHS Lothian, Edinburgh, UK.
Journal of pediatric gastroenterology and nutrition
|November 20, 2024
概括
阿片类药物用于治疗急性胰腺炎 (AP) 儿童的疼痛是常见的. 然而,最佳的疼痛管理策略及其长期影响仍然是未知的,这凸显了对儿科疼痛缓解的进一步研究的需要.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 疼痛管理 疼痛管理
- 基于证据的医学基于证据的医学.
背景情况:
- 急性胰腺炎 (AP) 是一个常见的儿科疾病.
- 儿科AP的最佳止痛实践缺乏强大的支持数据.
- 目前对儿科AP的止痛趋势和结果的理解有限.
研究的目的:
- 对儿科急性胰腺炎的止痛实践进行范围审查.
- 调查用于儿科AP的止痛策略的趋势.
- 评估不同止痛方式对患者结果的影响.
主要方法:
- 在主要数据库 (Medline,Embase,CENTRAL,Pubmed Central,Google Scholar) 进行系统的文献搜索.
- 两名独立调查人员进行了搜查.
- 遵守系统审查和元分析优先报告项目扩展范围审查 (PRISMA-ScR) 检查清单.
主要成果:
- 审查了三项涉及658名儿科患者的回顾性北美队列研究.
- 阿片类药物是最常见的止痛药 (59.5%),自2014/2017年以来,注册率有所下降.
- 关于乙氨基和NSAIDs的数据有限;没有关于并发症,生活质量或长期出院后使用的研究报告.
结论:
- 阿片类药物是北美儿科AP的主要止痛药选择.
- 关于影响止痛药选择,结果和长期使用的因素,存在重大知识差距.
- 进一步的研究是必不可少的,以建立基于证据的指导方针来管理儿科AP的疼痛.
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