在晚期肝细胞癌中全身疗法连续的α-fetoprotein的变化 - 一个现实世界的多中心研究
Michael Li1, Lindsay M Hannan2, Lipika Goyal3
1Division of Gastroenterology and Hepatology, Department of Medicine, University of California, San Francisco. 513 Parnassus Ave, S-357, San Francisco, CA 94143, USA.
Therapeutic advances in medical oncology
|November 20, 2024
概括
阿尔法胎蛋白 (AFP) 的早期变化预测了肝细胞癌 (HCC) 的治疗成功. 减少AFP表明索拉费尼布和检查点抑制剂治疗的生存时间和治疗时间更长.
科学领域:
- 肝胆瘤学 肝胆瘤学
- 医学瘤学 医学瘤学
- 翻译研究是翻译研究.
背景情况:
- 阿尔法-胎蛋白 (AFP) 变化是肝细胞癌 (HCC) 系统治疗结果的潜在代用终点.
- 评估不同治疗线的AFP反应效用对于优化HCC管理至关重要.
研究的目的:
- 在接受一线索拉费尼布 (1L SOR) 和随后的检查点抑制剂 (CPI) 治疗的高级HCC患者中,研究AFP反应对整体生存 (OS) 和治疗时间 (TOT) 的预测价值.
- 为了确定早期的AFP变化是否可以作为HCC系统治疗中可靠的代用终点.
主要方法:
- 进行了一项多中心的回顾性队列研究.
- 分析了接受1L SOR和任何随后的CPI的晚期HCC患者.
- 据定义,AFP反应是在3个月内减少≥20%;AFP进展是在3个月内增加≥20%.
主要成果:
- 在1L SOR上获得AFP反应的患者与不响应者或无价值患者相比,具有显著更长的OS和TOT.
- 在1L SOR上,AFP的进展与显著缩短的OS相关.
- 在CPI治疗后的AFP反应也与死亡风险显著降低相关.
结论:
- 在1L SOR和随后的CPI治疗期间,早期的AFP反应与改善的OS和TOT有关.
- 早期的AFP进展与更糟糕的OS和TOT有关.
- 纵向的AFP变化被认为是HCC系统治疗的有价值的替代终点.
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