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发明VH-937,一种强大的HIV-1成熟抑制剂,有可能在人体内不经常服用口服剂量

Sing-Yuen Sit1, Yan Chen1, Jie Chen1

  • 1Departments of Discovery Chemistry, Virology, Pharmaceutical Candidate Optimization, and Discovery Synthesis, Bristol Myers Squibb Research and Early Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.

ACS medicinal chemistry letters
|November 20, 2024
PubMed
概括

像VH-937这样的新型HIV-1成熟抑制剂显示出强烈的抗病毒活性和对抗性突变的有效性. 这种先进的化合物显示出在患者中方便每周服用一次剂量的潜力.

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