在持续使用阿尔布特罗尔治疗儿科关键性喘期间口服营养:一项匹配的队列研究
Maya Antionette Root1, Carolyn Maria Ibrahim Pavlich2, Anthony Alexander Sochet2,3
1Lincoln Memorial University-DeBusk College of Osteopathic Medicine, Harrogate, TN, USA.
Pediatric gastroenterology, hepatology & nutrition
|November 20, 2024
概括
拒绝为患有喘的重症儿童提供口服营养,并持续服用阿尔布特罗尔,并非基于证据. 这项研究发现,提供营养是安全的,耐受性良好,这表明目前的做法可能是不合理的.
科学领域:
- 儿科重症监护医学 儿科重症监护医学
- 呼吸系统医学 呼吸系统医学
- 临床营养学 临床营养学
背景情况:
- 对于接受连续阿尔布特罗尔的严重喘儿童拒绝口服营养的标准做法缺乏证据.
- 连续服用阿尔布特罗尔是一种常见的干预措施,用于儿童重症监护病房的严重喘恶化.
- 担心吸收风险的担忧往往导致被扣留营养支持.
研究的目的:
- 对于接受连续阿尔布特罗尔的患有喘的重症儿童的口服营养实践的特征.
- 在这个患者群体中估计吸入相关呼吸衰竭的频率.
- 为了评估口服营养在持续的阿尔布特罗尔治疗期间的安全性和耐受性.
主要方法:
- 进行了一项单一中心的回顾性,匹配的队列研究.
- 包括因严重喘而入住儿科重症监护室的3至17岁儿童,接受连续阿尔布特罗尔治疗.
- 接受口服营养的病例与根据年龄和喘严重程度而被拒绝营养的对照进行了1:2匹配.
主要成果:
- 在接受口服营养的儿童中没有观察到与吸入相关的呼吸衰竭事件,即使同时进行非侵入性通风.
- 与对照组相比,接受口服营养的儿童连续使用阿尔布特罗尔的持续时间较长.
- 两组之间在停留时间,输管率或死亡率方面没有发现显著差异.
结论:
- 口服营养似乎很好地耐受住院治疗严重喘的儿童,他们接受连续雾化阿尔布托罗尔.
- 在连续服用阿尔布特罗尔时,拒绝口服营养的做法可能是不必要的.
- 需要进一步的前性研究来验证这些发现.
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